bento.tl.lp_diff_continuous

bento.tl.lp_diff_continuous(sdata, instance_key='cell_boundaries', phenotype=None)

Gene-wise test for differential localization across phenotype of interest.

Parameters:

  • sdata (SpatialData) – Spatial formatted SpatialData object.

  • instance_key (str) – cell boundaries instance key.

  • phenotype (str) – Variable grouping cells for differential analysis. Must be in sdata.shape[“cell_boundaries].columns.

Returns:

sdata –

.table.uns[‘diff_{phenotype}’]

Long DataFrame with differential localization test results across phenotype groups.

Return type:

SpatialData